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DeCS
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Descriptor English:
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Spastic Paraplegia, Hereditary
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Descriptor Spanish:
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Paraplejía Espástica Hereditaria
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Descriptor Portuguese:
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Paraplegia Espástica Hereditária
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Synonyms English:
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Hereditary Spastic Paraplegia
X-Linked, Spastic Paraplegia, Hereditary
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Tree Number:
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C10.500.300.820
C10.574.500.495.820
C10.668.829.800.300.820
C16.131.666.300.820
C16.320.400.375.820
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Definition English:
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A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8) |
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Indexing Annotation English:
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coord with GENES, DOMINANT or GENES, RECESSIVE if discussed
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History Note English:
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1991(1989)
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Allowable Qualifiers English:
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Record Number:
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23835
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Unique Identifier:
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D015419
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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